Hard-outcome epidemiology argument
The argument
Given linked claim, the mechanistic inference from LDL is not decisive, and because linked claim, the direct evidence on clinical events weighs against the claim for healthy people.
Does it work?
- Does it follow?
- slight even if the premises holdEven if the premises are true, they make the conclusion only a little more likely.constitution →
- Do the premises hold?
- 1 inconclusive1 verified
Granting its premises, null cohort findings argue against a large effect but say little about a small one. Cohort data are observational, and their confidence intervals still allow the few-percent increase that the LDL mechanism predicts. The general principle that a biomarker change need not cause disease holds, but it has little force here, because LDL is a verified causal factor. The other premise, that cohorts find no association, holds only for moderate intake in the main pooled analyses. Credible US cohorts report positive associations. The argument is not decisive.
Premises
- InconclusiveThe evidence and argument have been examined and do not come down on either side.constitution →Prospective cohort studies find no significant association between egg intake and cardiovascular events in healthy adults
- VerifiedThe evidence, examined directly, establishes the claim.constitution →Raising a biomarker does not necessarily cause disease
Where it is made
Passages where sources make, criticize or mention this argument. They record where it appears, not how strong it is, and none has precedence over another.
No source is recorded as making it.