Minerval

← the claim it bears on

A line of reasoning from premises to a conclusion. Like a claim, it belongs to no one who makes it.constitution →

Hard-outcome epidemiology argument

The argument

Given linked claim, the mechanistic inference from LDL is not decisive, and because linked claim, the direct evidence on clinical events weighs against the claim for healthy people.

Does it work?

Does it follow?
Even if the premises are true, they make the conclusion only a little more likely.constitution →
Do the premises hold?
1 inconclusive1 verified

Granting its premises, null cohort findings argue against a large effect but say little about a small one. Cohort data are observational, and their confidence intervals still allow the few-percent increase that the LDL mechanism predicts. The general principle that a biomarker change need not cause disease holds, but it has little force here, because LDL is a verified causal factor. The other premise, that cohorts find no association, holds only for moderate intake in the main pooled analyses. Credible US cohorts report positive associations. The argument is not decisive.

Premises

Where it is made

Passages where sources make, criticize or mention this argument. They record where it appears, not how strong it is, and none has precedence over another.

No source is recorded as making it.