trailDietary cholesterol intake has only a weak, variable effect on blood cholesterol levels.
Dietary cholesterol intake is not consistently associated with cardiovascular disease risk in the general population.
Dietary cholesterol overconsumption is not a significant health concern.
Eggs' LDL-raising effect is caused by their saturated fat content, not their dietary cholesterol content.
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A subset of people (hyper-responders) experience substantial blood cholesterol increases from dietary cholesterol intake.
There is marked inter-individual variability in blood cholesterol response to dietary cholesterol intake.
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Dietary cholesterol intake suppresses endogenous cholesterol synthesis.
Increased intracellular cholesterol downregulates HMG-CoA reductase and cholesterol synthesis via the SREBP-2 pathway.
claim · empirical · verifiableA factual claim that could be checked directly against observation or primary records.constitution →claim page ↗︎
Dietary cholesterol intake has only a weak, variable effect on blood cholesterol levels.
↑SupportedEvidence favors the claim, but the chain is incomplete or the sources are secondary.constitution →credence 0.80Credence, from 0 to 1: the Steward's probability that the claim, as stated, is true. Stated only where a single number is an honest summary; normative and evaluative claims usually carry none.constitution →
6depended on by
this rests on ↓
claimA box is a claim: a single proposition the graph assesses, with its own page and map. Click any claim to centre the map on it.constitution →argumentA pill is an argument: one line of reasoning stating how the claims beneath it combine to bear on the claim above it, for or against. Arguments are not destinations; click their claims to explore.constitution →✓verifiedThe claim traces to reliable primary sources through a clear chain of evidence.constitution →↑supportedEvidence favors the claim, but the chain is incomplete or the sources are secondary.constitution →⇄contestedCredible evidence or argument exists on multiple sides.constitution →○unsupportedNo credible evidence found, though the claim is not contradicted.constitution →✕contradictedAvailable evidence weighs against the claim.constitution →?unknownInsufficient information to assess.constitution →◌unassessedNo current assessment — the Steward prioritises higher-importance claims, so this one is likely still queued.constitution →verified factopen questionvalue premisesupportsthis provides evidence for the parentsteward instructions →contradictsthis argues against the parentsteward instructions →assumesbackground the parent's framing takes as givensteward instructions →requiresa load-bearing premise: the parent is false without itsteward instructions →Fig. — detail falls off with distance; every claim is an address.