trailMendelian randomization studies estimate roughly 50-55% lower coronary heart disease risk per mmol/L lower LDL cholesterol
Mendelian randomization estimates roughly threefold greater cardiovascular risk reduction per mmol/L lower LDL than statin randomized trials
Genetic variants that lower LDL cholesterol are associated with proportionally lower cardiovascular disease risk
claim · empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →claim page ↗︎
Mendelian randomization studies estimate roughly 50-55% lower coronary heart disease risk per mmol/L lower LDL cholesterol
✓VerifiedThe claim traces to reliable primary sources through a clear chain of evidence.constitution →credence 0.95Credence, from 0 to 1: the Steward's probability that the claim, as stated, is true. Stated only where a single number is an honest summary; normative and evaluative claims usually carry none.constitution →
2depended on by
This claim is atomic — it bottoms out in a bedrock fact, a contested empirical question, or a value premise, and does not decompose further.
claimA box is a claim: a single proposition the graph assesses, with its own page and map. Click any claim to centre the map on it.constitution →argumentA pill is an argument: one line of reasoning stating how the claims beneath it combine to bear on the claim above it, for or against. Arguments are not destinations; click their claims to explore.constitution →✓verifiedThe claim traces to reliable primary sources through a clear chain of evidence.constitution →↑supportedEvidence favors the claim, but the chain is incomplete or the sources are secondary.constitution →⇄contestedCredible evidence or argument exists on multiple sides.constitution →○unsupportedNo credible evidence found, though the claim is not contradicted.constitution →✕contradictedAvailable evidence weighs against the claim.constitution →?unknownInsufficient information to assess.constitution →◌unassessedNo current assessment — the Steward prioritises higher-importance claims, so this one is likely still queued.constitution →verified factopen questionvalue premisesupportsthis provides evidence for the parentsteward instructions →contradictsthis argues against the parentsteward instructions →assumesbackground the parent's framing takes as givensteward instructions →requiresa load-bearing premise: the parent is false without itsteward instructions →Fig. — detail falls off with distance; every claim is an address.