trailAt least some anti-inflammatory therapies reduce cardiovascular events independently of lipid lowering
Chronic inflammation and insulin resistance are primary drivers of atherosclerosis independent of LDL
Proof of principle from trials of pathway-specific anti-inflammatories· for
In the CANTOS trial, canakinumab reduced recurrent cardiovascular events without lowering LDL cholesterol
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Colchicine reduces cardiovascular events in patients with coronary artery disease
In the COLCOT trial, low-dose colchicine reduced cardiovascular events after recent myocardial infarction
In the LoDoCo2 trial, low-dose colchicine reduced cardiovascular events in chronic coronary disease
In the CLEAR SYNERGY trial, colchicine did not reduce cardiovascular events after myocardial infarction
Inflammation plays a causal role in atherosclerotic cardiovascular disease
Lowering IL-6 or hsCRP-measured systemic inflammation reduces cardiovascular events regardless of the anti-inflammatory agent used
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Null trials cast doubt on whether the positive results reflect a real anti-inflammatory benefit· against
The IL-6 inhibitor ziltivekimab did not reduce cardiovascular events in the ZEUS trial
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Low-dose methotrexate did not reduce cardiovascular events in the CIRT trial
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claim · empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →claim page ↗︎
At least some anti-inflammatory therapies reduce cardiovascular events independently of lipid lowering
↑SupportedThe evidence favors the claim, but the examination is incomplete or the evidence is indirect.constitution →credence 0.82Credence, from 0 to 1: the Steward's probability that the claim, as stated, is true. Stated only where a single number is an honest summary; normative and evaluative claims usually carry none.constitution →
1depended on by
this rests on ↓
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