trailMendelian randomization estimates roughly threefold greater cardiovascular risk reduction per mmol/L lower LDL than statin randomized trials
Mendelian randomization and statin-trial estimates of LDL's cardiovascular effect are mutually consistent once duration of exposure is accounted for
Genetic vs trial per-unit estimates· for
Mendelian randomization studies estimate roughly 50-55% lower coronary heart disease risk per mmol/L lower LDL cholesterol
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Statin randomized trials reduce major vascular events by about a fifth per 1 mmol/L reduction in LDL cholesterol
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The cardiovascular risk reduction per unit of LDL lowering increases with longer duration of exposure
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claim · empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →claim page ↗︎
Mendelian randomization estimates roughly threefold greater cardiovascular risk reduction per mmol/L lower LDL than statin randomized trials
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1depended on by
this rests on ↓
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