trailRandomized trials show lowering LDL cholesterol reduces cardiovascular events proportionally to the reduction achieved
Elevated LDL cholesterol causes cardiovascular disease
Mendelian randomization studies show genetically lower LDL cholesterol causally reduces cardiovascular disease risk
Adding ezetimibe to statin therapy reduces cardiovascular events
Statin randomized trials reduce major vascular events by about a fifth per 1 mmol/L reduction in LDL cholesterol
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Non-statin LDL-lowering therapies reduce cardiovascular events proportionally to the LDL reduction achieved
PCSK9 inhibitors reduce cardiovascular events in statin-treated patients
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Some interventions that lower LDL cholesterol failed to reduce cardiovascular events
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claim · empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →claim page ↗︎
Randomized trials show lowering LDL cholesterol reduces cardiovascular events proportionally to the reduction achieved
✓VerifiedThe claim traces to reliable primary sources through a clear chain of evidence.constitution →credence 0.90Credence, from 0 to 1: the Steward's probability that the claim, as stated, is true. Stated only where a single number is an honest summary; normative and evaluative claims usually carry none.constitution →
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this rests on ↓
claimA box is a claim: a single proposition the graph assesses, with its own page and map. Click any claim to centre the map on it.constitution →argumentA pill is an argument: one line of reasoning stating how the claims beneath it combine to bear on the claim above it, for or against. Arguments are not destinations; click their claims to explore.constitution →✓verifiedThe claim traces to reliable primary sources through a clear chain of evidence.constitution →↑supportedEvidence favors the claim, but the chain is incomplete or the sources are secondary.constitution →⇄contestedCredible evidence or argument exists on multiple sides.constitution →○unsupportedNo credible evidence found, though the claim is not contradicted.constitution →✕contradictedAvailable evidence weighs against the claim.constitution →?unknownInsufficient information to assess.constitution →◌unassessedNo current assessment — the Steward prioritises higher-importance claims, so this one is likely still queued.constitution →verified factopen questionvalue premisesupportsthis provides evidence for the parentsteward instructions →contradictsthis argues against the parentsteward instructions →assumesbackground the parent's framing takes as givensteward instructions →requiresa load-bearing premise: the parent is false without itsteward instructions →Fig. — detail falls off with distance; every claim is an address.