trailInsulin resistance is an independent risk factor for atherosclerotic cardiovascular disease
Chronic inflammation and insulin resistance are primary drivers of atherosclerosis independent of LDL
Prospective and genetic evidence· for
Insulin resistance measured by surrogate indices predicts incident cardiovascular events after adjustment for conventional risk factors
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Genetically predicted insulin resistance is associated with increased coronary artery disease risk
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Pioglitazone reduces the risk of major adverse cardiovascular events
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Mediation critique· against
The cardiovascular risk associated with insulin resistance is largely mediated through atherogenic dyslipidemia and blood pressure
Insulin resistance produces atherogenic dyslipidemia: elevated triglycerides, low HDL, and small dense LDL particles
Insulin resistance contributes causally to elevated blood pressure
The association between insulin resistance and cardiovascular events attenuates substantially after adjusting for lipids and blood pressure
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claim · empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →claim page ↗︎
Insulin resistance is an independent risk factor for atherosclerotic cardiovascular disease
↑SupportedEvidence favors the claim, but the chain is incomplete or the sources are secondary.constitution →credence 0.70Credence, from 0 to 1: the Steward's probability that the claim, as stated, is true. Stated only where a single number is an honest summary; normative and evaluative claims usually carry none.constitution →
1depended on by
this rests on ↓
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