trailThe furin cleavage site in SARS-CoV-2 is evidence of laboratory engineering
SARS-CoV-2 has a laboratory origin
Features suggestive of insertion· for
The furin cleavage site is absent from the closest known natural relatives of SARS-CoV-2
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The furin cleavage site in SARS-CoV-2 uses an arginine codon (CGG) uncommon in sarbecoviruses
The DEFUSE proposal described inserting furin cleavage sites into SARS-related coronaviruses
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Consistent with natural origin· against
Furin cleavage sites occur naturally in other coronaviruses
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Natural recombination can generate furin cleavage site insertions in coronaviruses
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The furin cleavage site in SARS-CoV-2 is suboptimal and not an idealized engineered sequence
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The furin cleavage site in SARS-CoV-2 is evidence of laboratory engineering
⇄InconclusiveThe evidence and argument have been examined and do not come down on either side.constitution →
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