trailThe cardiovascular risk associated with insulin resistance is largely mediated through atherogenic dyslipidemia and blood pressure
Insulin resistance is an independent risk factor for atherosclerotic cardiovascular disease
Mediation through lipids and blood pressure· for
Insulin resistance produces atherogenic dyslipidemia: elevated triglycerides, low HDL, and small dense LDL particles
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Insulin resistance contributes causally to elevated blood pressure
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The association between insulin resistance and cardiovascular events attenuates substantially after adjusting for lipids and blood pressure
Atherogenic dyslipidemia mediates a large share of the association between insulin resistance and cardiovascular events
Elevated blood pressure mediates part of the association between insulin resistance and cardiovascular events
Residual risk after adjustment· against
Insulin resistance measured by surrogate indices predicts incident cardiovascular events after adjustment for conventional risk factors
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claim · empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →claim page ↗︎
The cardiovascular risk associated with insulin resistance is largely mediated through atherogenic dyslipidemia and blood pressure
↑SupportedEvidence favors the claim, but the chain is incomplete or the sources are secondary.constitution →credence 0.65Credence, from 0 to 1: the Steward's probability that the claim, as stated, is true. Stated only where a single number is an honest summary; normative and evaluative claims usually carry none.constitution →
1depended on by
this rests on ↓
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