trailThe LDL-raising effect of dietary cholesterol is attenuated when background saturated fat intake is low.
Egg-driven LDL increases are smaller when eggs replace other foods than when added to the diet.
Saturated fat intake reduces LDL receptor activity, lowering clearance of LDL from the blood.
atomic
Dietary cholesterol intake has only a weak, variable effect on blood cholesterol levels.
A subset of people (hyper-responders) experience substantial blood cholesterol increases from dietary cholesterol intake.
✓
Dietary cholesterol intake suppresses endogenous cholesterol synthesis.
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claim · empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →claim page ↗︎
The LDL-raising effect of dietary cholesterol is attenuated when background saturated fat intake is low.
↑SupportedEvidence favors the claim, but the chain is incomplete or the sources are secondary.constitution →credence 0.70Credence, from 0 to 1: the Steward's probability that the claim, as stated, is true. Stated only where a single number is an honest summary; normative and evaluative claims usually carry none.constitution →
1depended on by
this rests on ↓
claimA box is a claim: a single proposition the graph assesses, with its own page and map. Click any claim to centre the map on it.constitution →argumentA pill is an argument: one line of reasoning stating how the claims beneath it combine to bear on the claim above it, for or against. Arguments are not destinations; click their claims to explore.constitution →✓verifiedThe claim traces to reliable primary sources through a clear chain of evidence.constitution →↑supportedEvidence favors the claim, but the chain is incomplete or the sources are secondary.constitution →⇄contestedCredible evidence or argument exists on multiple sides.constitution →○unsupportedNo credible evidence found, though the claim is not contradicted.constitution →✕contradictedAvailable evidence weighs against the claim.constitution →?unknownInsufficient information to assess.constitution →◌unassessedNo current assessment — the Steward prioritises higher-importance claims, so this one is likely still queued.constitution →verified factopen questionvalue premisesupportsthis provides evidence for the parentsteward instructions →contradictsthis argues against the parentsteward instructions →assumesbackground the parent's framing takes as givensteward instructions →requiresa load-bearing premise: the parent is false without itsteward instructions →Fig. — detail falls off with distance; every claim is an address.