trailHigh egg consumption is associated with increased cardiovascular disease risk in a dose-response manner.
Pooled-cohort and mechanistic support· for
Large pooled cohort studies find a dose-response association between dietary cholesterol intake and cardiovascular disease or mortality.
Zhong et al. (2019) pooled analysis found each additional 300 mg/day dietary cholesterol associated with higher cardiovascular disease risk in dose-response fashion.
Adding eggs to the diet raises LDL cholesterol compared to a no-egg diet.
Meta-analyses of randomized controlled trials find egg consumption modestly increases LDL cholesterol.
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Eggs' LDL-raising effect is caused by their saturated fat content, not their dietary cholesterol content.
Dietary cholesterol intake has only a weak, variable effect on blood cholesterol levels.
Elevated LDL cholesterol causes cardiovascular disease
Mendelian randomization studies show genetically lower LDL cholesterol causally reduces cardiovascular disease risk
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LDL particles accumulating in the arterial wall initiate and drive atherosclerosis
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Null and heterogeneous findings· against
Prospective cohort studies find no significant association between egg intake and cardiovascular events in healthy adults
Prospective cohort studies show positive egg–cardiovascular disease associations in US populations but null associations in European and Asian populations.
shared · shown elsewhere
Positive egg–cardiovascular disease associations are concentrated among people with diabetes.
shared · shown elsewhere
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claim · empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →claim page ↗︎
High egg consumption is associated with increased cardiovascular disease risk in a dose-response manner.
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