Claims
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KindShowingImportancePrizesTopicCardiovascular medicine
The medical specialty dealing with disorders of the heart and circulatory system, including their prevention, diagnosis, and treatment.
At least some anti-inflammatory therapies reduce cardiovascular events independently of lipid lowering
SupportedThe evidence favors the claim, but the examination is incomplete or the evidence is indirect.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Inflammation in atherosclerosisAtherosclerotic cardiovascular diseaseimportance · majorImportance 0.65, from 0 to 1 · major: real consequence within a domain, actively argued. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Colchicine reduces cardiovascular events in patients with coronary artery disease
SupportedThe evidence favors the claim, but the examination is incomplete or the evidence is indirect.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →ColchicineCoronary artery diseaseimportance · notableImportance 0.60, from 0 to 1 · notable: a contested point in a live debate (also the default before judging). Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Some interventions that lower LDL cholesterol failed to reduce cardiovascular events
VerifiedThe evidence, examined directly, establishes the claim.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →LDL cholesterolAtherosclerotic cardiovascular diseaseimportance · minorImportance 0.40, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Elevated LDL cholesterol causes cardiovascular disease
VerifiedThe evidence, examined directly, establishes the claim.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →LDL cholesterolAtherosclerotic cardiovascular diseaseimportance · majorImportance 0.80, from 0 to 1 · major: real consequence within a domain, actively argued. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
In the COLCOT trial, low-dose colchicine reduced cardiovascular events after recent myocardial infarction
UnassessedNo current assessment. Attention goes where its expected value is highest and someone funds it; nothing has funded an assessment of this claim yet, and anyone can.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →ColchicineCOLCOT trialInflammation in atherosclerosisimportance · minorImportance 0.25, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Insulin resistance contributes causally to elevated blood pressure
UnassessedNo current assessment. Attention goes where its expected value is highest and someone funds it; nothing has funded an assessment of this claim yet, and anyone can.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Insulin resistanceHypertensionimportance · minorImportance 0.30, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
PCSK9 inhibitors substantially lower LDL cholesterol when added to statin therapy
UnassessedNo current assessment. Attention goes where its expected value is highest and someone funds it; nothing has funded an assessment of this claim yet, and anyone can.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →PCSK9 inhibitorsLDL cholesterolimportance · settledImportance 0.15, from 0 to 1 · settled: uncontested, so low even when much depends on it. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
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