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The randomized 2x2 CLEAR SYNERGY (OCEAN) trial in patients with STEMI, testing colchicine 0.5 mg/day versus placebo and spironolactone versus placebo after infarction: its design, cardiovascular event outcomes, subgroup findings, and interpretation. Not for other post-MI prevention trials.

In the CLEAR SYNERGY trial, colchicine did not reduce cardiovascular events after myocardial infarction

UnassessedNo current assessment. Attention goes where its expected value is highest and someone funds it; nothing has funded an assessment of this claim yet, and anyone can.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Colchicine Atherosclerotic cardiovascular disease Inflammation in atherosclerosisimportance · minorImportance 0.30, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →

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