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4 claims

Elevated blood pressure and hypertension as a condition and cardiovascular risk factor: its measurement, determinants, and role in mediating risk of atherosclerotic events, including blood-pressure-lowering evidence. Not for blood-pressure findings unrelated to cardiovascular outcomes.

The cardiovascular risk associated with insulin resistance is largely mediated through atherogenic dyslipidemia and blood pressure

SupportedEvidence favors the claim, but the chain is incomplete or the sources are secondary.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Atherogenic dyslipidemia Insulin resistance Atherosclerotic cardiovascular diseaseimportance · minorImportance 0.40, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →

The association between insulin resistance and cardiovascular events attenuates substantially after adjusting for lipids and blood pressure

SupportedEvidence favors the claim, but the chain is incomplete or the sources are secondary.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Insulin resistance Atherosclerotic cardiovascular disease Atherogenic dyslipidemiaimportance · minorImportance 0.42, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →

Elevated blood pressure mediates part of the association between insulin resistance and cardiovascular events

UnassessedNo current assessment. Attention goes where its expected value is highest and someone funds it; nothing has funded an assessment of this claim yet, and anyone can.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Insulin resistance Atherosclerotic cardiovascular diseaseimportance · minorImportance 0.30, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →

Insulin resistance contributes causally to elevated blood pressure

UnassessedNo current assessment. Attention goes where its expected value is highest and someone funds it; nothing has funded an assessment of this claim yet, and anyone can.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Insulin resistance Cardiovascular medicineimportance · minorImportance 0.30, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →

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