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ShowingImportancePrizesTopicInsulin resistance
Reduced sensitivity of liver, muscle, and adipose tissue to insulin's actions, with compensatory hyperinsulinemia and progression toward type 2 diabetes and metabolic syndrome. Use for claims studying insulin resistance itself, including its role as a risk factor for atherosclerotic cardiovascular disease, nonalcoholic fatty liver, and other cardiometabolic outcomes.
Insulin resistance measured by surrogate indices predicts incident cardiovascular events after adjustment for conventional risk factors
UnassessedNo current assessment. Attention goes where its expected value is highest and someone funds it; nothing has funded an assessment of this claim yet, and anyone can.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Atherosclerotic cardiovascular diseaseimportance · minorImportance 0.35, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Insulin resistance is an independent risk factor for atherosclerotic cardiovascular disease
SupportedEvidence favors the claim, but the chain is incomplete or the sources are secondary.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Atherosclerotic cardiovascular diseaseimportance · notableImportance 0.45, from 0 to 1 · notable: a contested point in a live debate (also the default before judging). Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
The cardiovascular risk associated with insulin resistance is largely mediated through atherogenic dyslipidemia and blood pressure
SupportedEvidence favors the claim, but the chain is incomplete or the sources are secondary.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Atherogenic dyslipidemiaAtherosclerotic cardiovascular diseaseHypertensionimportance · minorImportance 0.40, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
The association between insulin resistance and cardiovascular events attenuates substantially after adjusting for lipids and blood pressure
SupportedEvidence favors the claim, but the chain is incomplete or the sources are secondary.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Atherosclerotic cardiovascular diseaseAtherogenic dyslipidemiaHypertensionimportance · minorImportance 0.42, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Elevated blood pressure mediates part of the association between insulin resistance and cardiovascular events
UnassessedNo current assessment. Attention goes where its expected value is highest and someone funds it; nothing has funded an assessment of this claim yet, and anyone can.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →HypertensionAtherosclerotic cardiovascular diseaseimportance · minorImportance 0.30, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Atherogenic dyslipidemia mediates a large share of the association between insulin resistance and cardiovascular events
UnassessedNo current assessment. Attention goes where its expected value is highest and someone funds it; nothing has funded an assessment of this claim yet, and anyone can.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Atherogenic dyslipidemiaAtherosclerotic cardiovascular diseaseimportance · minorImportance 0.35, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Genetically predicted insulin resistance is associated with increased coronary artery disease risk
UnassessedNo current assessment. Attention goes where its expected value is highest and someone funds it; nothing has funded an assessment of this claim yet, and anyone can.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Coronary artery diseaseMendelian randomizationimportance · minorImportance 0.30, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Insulin resistance contributes causally to elevated blood pressure
UnassessedNo current assessment. Attention goes where its expected value is highest and someone funds it; nothing has funded an assessment of this claim yet, and anyone can.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →HypertensionCardiovascular medicineimportance · minorImportance 0.30, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Chronic inflammation and insulin resistance are primary drivers of atherosclerosis independent of LDL
ContradictedAvailable evidence weighs against the claim.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Inflammation in atherosclerosisAtherosclerotic cardiovascular diseaseLDL cholesterolimportance · notableImportance 0.50, from 0 to 1 · notable: a contested point in a live debate (also the default before judging). Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
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