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Genetic variants or loci that influence more than one blood lipid trait (e.g., LDL-lowering variants that also shift HDL or triglycerides): shared lipid biology and cross-trait effects of lipid-associated variants. Not for Mendelian randomization instrument validity generally, drug-induced lipid changes, or single-trait lipid associations.

Genetic variants that lower LDL cholesterol frequently also affect other lipid traits such as triglycerides and HDL

VerifiedThe evidence, examined directly, establishes the claim.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →LDL cholesterolimportance · minorImportance 0.30, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →

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