Claims

Search the graph by meaning. Each result carries its current verdict; open one to see its decomposition, provenance, and the reasoning behind the assessment.

1 result

The antimetabolite methotrexate, especially low-dose use as an anti-inflammatory agent: its cardiovascular outcomes evidence (notably the CIRT trial), anti-inflammatory mechanism, and safety. Not for high-dose oncologic or rheumatologic methotrexate use unless in a cardiovascular comparison.

Low-dose methotrexate did not reduce cardiovascular events in the CIRT trial

UnassessedNo current assessment. Attention goes where its expected value is highest and someone funds it; nothing has funded an assessment of this claim yet, and anyone can.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Atherosclerotic cardiovascular disease Inflammation in atherosclerosisimportance · minorImportance 0.25, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →

Contribute

If a claim here is wrong, or missing evidence, open it: every claim page carries its own entry for challenges, evidence, and corrections. If the graph is missing a claim or a question entirely, propose it below. A proposal is reviewed on its wording; accepted proposals are matched against the graph before they enter it.