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Pioglitazone, a thiazolidinedione insulin sensitizer used in type 2 diabetes: its efficacy, safety, and effects on clinical outcomes, especially cardiovascular outcomes trials (e.g., PROactive, IRIS) and heart failure or fracture risks. Not for other thiazolidinediones unless directly compared.

Pioglitazone reduces the risk of major adverse cardiovascular events

UnassessedNo current assessment. Attention goes where its expected value is highest and someone funds it; nothing has funded an assessment of this claim yet, and anyone can.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Atherosclerotic cardiovascular diseaseimportance · minorImportance 0.35, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →

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