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The case for a natural (zoonotic) origin at the Huanan market

Michael Worobey, Joshua I. Levy, Lorena Malpica Serrano, Alexander Crits-Christoph, Jonathan E. Pekar, Stephen A. Goldstein, Angela L. Rasmussen, Moritz U. G. Kraemer, Chris Newman, Marion P. G. Koopmans, Marc A. Suchard, Joel O. Wertheim, Philippe Lemey, David L. Robertson, Robert F. Garry, Edward C. Holmes, Andrew Rambaut, Kristian G. AndersenSciencePublished Aug 26, 2022doi 10.1126/science.abp8715 Original︎ ↗Archived copy

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We show here that the earliest known COVID-19 cases from December 2019, including those without reported direct links, were geographically centered on this market. We report that live SARS-CoV-2–susceptible mammals were sold at the market in late 2019 and that within the market, SARS-CoV-2–positive environmental samples were spatially associated with vendors selling live mammals.

SARS-CoV-2 originated through zoonotic spillover at the Huanan Seafood Market in WuhanSupported

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Kind: journal article
Authors: Michael Worobey, Joshua I. Levy, Lorena Malpica Serrano, Alexander Crits-Christoph, Jonathan E. Pekar, Stephen A. Goldstein, Angela L. Rasmussen, Moritz U. G. Kraemer, Chris Newman, Marion P. G. Koopmans, Marc A. Suchard, Joel O. Wertheim, Philippe Lemey, David L. Robertson, Robert F. Garry, Edward C. Holmes, Andrew Rambaut, Kristian G. Andersen
Publisher: Science
Published: Aug 26, 2022
DOI: 10.1126/science.abp8715
Link: https://www.science.org/doi/10.1126/science.abp8715
Archived copy: https://web.archive.org/web/20251211112532/https://www.science.org/doi/10.1126/science.abp8715
Stored text: 4,565 characters, retrieved Jun 24, 2026 · 1 sections, 8 passages
Claims extracted: Not recorded
Versions: One known
Copies: None recorded
Corrections: None recorded
Facts checked: Nov 9, 2026

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