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The Data are Insufficient to Confidently Root the SARS-CoV-2 Phylogenetic Tree

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Lv et al. (2024) confirmed the existence of sequences with a T8782 / T28144 genotype genetically intermediate between lineages A and B. ... whether these sequences should actually all be removed remains a topic of debate (Pekar et al.).

Intermediate A-B SARS-CoV-2 genomes existed among early human casesInconclusive

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I also demonstrate clear evidence of bias among the earliest available sequences, and explain why the root of the SARS-CoV-2 tree cannot be conclusively resolved with the current data.

Early SARS-CoV-2 genomic data are insufficient to confidently root the phylogenetic tree by phylogenetic methods aloneSupported

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The Data are Insufficient to Confidently Root the SARS-CoV-2 Phylogenetic Tree

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Link: https://pmc.ncbi.nlm.nih.gov/articles/PMC12147021/
Archived copy: https://web.archive.org/web/20260326224705/https://pmc.ncbi.nlm.nih.gov/articles/PMC12147021/
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Versions: One known
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Facts checked: Nov 9, 2026

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Nov 9, 2026FactsFacts fetcher · Facts looked up
Nov 7, 2026Entered the graphEntered the graph; no copy stored