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Phylogenetic Analysis of SARS-CoV-2 Data Is Difficult

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We find that rooting the inferred phylogeny with some degree of confidence either via the bat and pangolin outgroups or by applying novel computational methods on the ingroup phylogeny does not appear to be possible. ... Thus, we conclude that the root of the SARS-CoV-2 phylogeny cannot be reliably determined via the methods we have applied here.

The correct rooting of the early SARS-CoV-2 phylogenetic tree is uncertainSupported

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Link: https://academic.oup.com/mbe/article/38/5/1777/6030946
Archived copy: https://web.archive.org/web/20260607101433/https://academic.oup.com/mbe/article/38/5/1777/6030946
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Versions: One known
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Facts checked: Nov 9, 2026

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Nov 9, 2026FactsFacts fetcher · Facts looked up
Nov 7, 2026Entered the graphEntered the graph; no copy stored