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ShowingImportancePrizesTopicDietary cholesterol
Cholesterol contained in food, particularly from animal products such as eggs, meat, and dairy, and research on its absorption, metabolism, and health effects including its relationship with blood lipid levels and cardiovascular disease.
Meta-analyses of randomized controlled trials find egg consumption modestly increases LDL cholesterol.
VerifiedThe claim traces to reliable primary sources through a clear chain of evidence.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Egg consumptionNutritionLDL cholesterolimportance · minorImportance 0.30, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
The LDL-raising effect of dietary cholesterol is attenuated when background saturated fat intake is low.
SupportedEvidence favors the claim, but the chain is incomplete or the sources are secondary.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Saturated fatNutritionLDL cholesterolimportance · minorImportance 0.30, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
There is marked inter-individual variability in blood cholesterol response to dietary cholesterol intake.
VerifiedThe claim traces to reliable primary sources through a clear chain of evidence.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →NutritionPrecision nutritionLDL cholesterolimportance · minorImportance 0.32, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Zhong et al. (2019) pooled analysis found each additional 300 mg/day dietary cholesterol associated with higher cardiovascular disease risk in dose-response fashion.
VerifiedThe claim traces to reliable primary sources through a clear chain of evidence.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →NutritionAtherosclerotic cardiovascular diseaseEgg consumptionimportance · settledImportance 0.20, from 0 to 1 · settled: uncontested, so low even when much depends on it. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
A subset of people (hyper-responders) experience substantial blood cholesterol increases from dietary cholesterol intake.
SupportedEvidence favors the claim, but the chain is incomplete or the sources are secondary.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →importance · minorImportance 0.35, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Prospective cohort studies generally show no significant independent association between dietary cholesterol and cardiovascular disease.
ContestedCredible evidence or argument exists on multiple sides.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Atherosclerotic cardiovascular diseaseNutritionimportance · notableImportance 0.45, from 0 to 1 · notable: a contested point in a live debate (also the default before judging). Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Egg-driven LDL increases are smaller when eggs replace other foods than when added to the diet.
SupportedEvidence favors the claim, but the chain is incomplete or the sources are secondary.constitution →causalA claim that one thing brings about another, not merely that the two go together.constitution →Egg consumptionLDL cholesterolFood substitution and net dietary effectsimportance · minorImportance 0.30, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Dietary cholesterol intake is not consistently associated with cardiovascular disease risk in the general population.
ContestedCredible evidence or argument exists on multiple sides.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Atherosclerotic cardiovascular diseaseNutritionimportance · notableImportance 0.60, from 0 to 1 · notable: a contested point in a live debate (also the default before judging). Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Adding eggs to the diet raises LDL cholesterol compared to a no-egg diet.
SupportedEvidence favors the claim, but the chain is incomplete or the sources are secondary.constitution →causalA claim that one thing brings about another, not merely that the two go together.constitution →Egg consumptionNutritionLDL cholesterolimportance · minorImportance 0.40, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Dietary cholesterol intake has only a weak, variable effect on blood cholesterol levels.
SupportedEvidence favors the claim, but the chain is incomplete or the sources are secondary.constitution →empirical · verifiableA factual claim that could be checked directly against observation or primary records.constitution →Nutritionimportance · notableImportance 0.55, from 0 to 1 · notable: a contested point in a live debate (also the default before judging). Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Dietary cholesterol overconsumption is not a significant health concern.
ContestedCredible evidence or argument exists on multiple sides.constitution →evaluativeA judgment of worth or quality against some standard: good, fair, effective.constitution →Nutritionimportance · notableImportance 0.55, from 0 to 1 · notable: a contested point in a live debate (also the default before judging). Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Regular egg consumption increases cardiovascular disease risk in healthy people
ContestedCredible evidence or argument exists on multiple sides.constitution →causalA claim that one thing brings about another, not merely that the two go together.constitution →Egg consumptionAtherosclerotic cardiovascular diseaseimportance · notableImportance 0.60, from 0 to 1 · notable: a contested point in a live debate (also the default before judging). Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Large pooled cohort studies find a dose-response association between dietary cholesterol intake and cardiovascular disease or mortality.
SupportedEvidence favors the claim, but the chain is incomplete or the sources are secondary.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →NutritionAtherosclerotic cardiovascular diseaseimportance · notableImportance 0.50, from 0 to 1 · notable: a contested point in a live debate (also the default before judging). Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Eggs' LDL-raising effect is caused by their saturated fat content, not their dietary cholesterol content.
SupportedEvidence favors the claim, but the chain is incomplete or the sources are secondary.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Egg consumptionNutritionSaturated fatimportance · notableImportance 0.50, from 0 to 1 · notable: a contested point in a live debate (also the default before judging). Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Dietary cholesterol intake is confounded with saturated fat and other dietary risk factors.
VerifiedThe claim traces to reliable primary sources through a clear chain of evidence.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →NutritionDietary exposure confoundingSaturated fatimportance · minorImportance 0.30, from 0 to 1 · minor: narrow or largely settled, cheap to get right. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Individuals differ substantially in the efficiency of intestinal cholesterol absorption.
UnassessedNo current assessment. Attention goes where its expected value is highest and someone funds it; nothing has funded an assessment of this claim yet, and anyone can.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →Precision nutritionimportance · settledImportance 0.20, from 0 to 1 · settled: uncontested, so low even when much depends on it. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
High dietary cholesterol intake correlates with other unhealthy dietary and lifestyle risk factors.
UnassessedNo current assessment. Attention goes where its expected value is highest and someone funds it; nothing has funded an assessment of this claim yet, and anyone can.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →NutritionDietary exposure confoundingimportance · settledImportance 0.20, from 0 to 1 · settled: uncontested, so low even when much depends on it. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
In typical Western diets, dietary cholesterol intake is positively correlated with saturated fat intake.
UnassessedNo current assessment. Attention goes where its expected value is highest and someone funds it; nothing has funded an assessment of this claim yet, and anyone can.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →NutritionSaturated fatDietary exposure confoundingimportance · settledImportance 0.20, from 0 to 1 · settled: uncontested, so low even when much depends on it. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
Eggs are relatively low in saturated fat but high in dietary cholesterol.
UnassessedNo current assessment. Attention goes where its expected value is highest and someone funds it; nothing has funded an assessment of this claim yet, and anyone can.constitution →empirical · derivedA factual claim that rests on inference from other evidence rather than direct observation.constitution →NutritionSaturated fatEgg consumptionimportance · settledImportance 0.15, from 0 to 1 · settled: uncontested, so low even when much depends on it. Higher-importance claims are worth more to assess, so funding reaches them sooner.constitution →
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